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Addictions RSS FeedsGoogle Algorithm Finds Cancer Biomarkers - Seven proteins that can help physicians evaluate how aggressive a patient's cancer is and whether or not they should receive chemotherapy have been identified by German researchers. Using a strategy similar to Google's PageRank algorithm, the researchers from Dresden University of Technology, Germany, were able to rank around 20,000 proteins by their genetic relevance to the progression of pancreatic cancer. The study is published in PLoS Computational Biology ...Feed Source: feedproxy.google.com Should Children Be Made To Have Vaccines? - Two experts discuss in the journal BMJ whether childhood vaccination should be mandatory in the UK. According to Paul Offit, Chief of Infectious diseases at the Children's Hospital of Philadelphia, mandatory vaccination is essential to protect those who are vulnerable from infection ... Controlling Blood Pressure - Team Based Care Vital - High blood pressure was listed as a primary or contributing cause of death for approximately 336,000 Americans in 2007. If all patients with high blood pressure were treated to goal as outlined in current clinical guidelines, it is estimated that 46,000 deaths might be averted each year. Total annual costs associated with hypertension are $156 billion, including medical costs of $131 billion and lost productivity costs of $25 billion. The Task Force on Community Preventive Services recommends team-based care (TBC) to improve blood pressure (BP) control ... General Practice - Uk India Partnership Initiative - â?¨â?¨An article featured in BMJ reports on a 'white paper', which investigates as to how India and the UK can collaborate more closely in an equal partnership to improve both nations' primary health care. â?¨The paper lists a number of opportunities based on India's plans to achieve Universal Health Coverage, which requires the collaboration of the UK and India to benefit both nations by strengthening primary care in India and bringing expertise and innovations from India to improve care in the UK ... Brushing Teeth - Which Way Is The Right Way? - Twenty five percent of teenagers in Sweden do not brush their teeth regularly and only 10% of Swedes know how to use toothpaste effectively, according to researchers at the Sahlgrenska Academy, University of Gothenburg. Even though the majority of people in Sweden brush their teeth, only 1 in 10 brush in a way that effectively prevents tooth decay. Pia Gabre and her colleagues examined the toothbrushing habits of 2,013 Swedes aged between 15 to 80 years old ... Palpitations May Mean Looming Atrial Fibrillation - The European Journal of Preventive Cardiology reveals that the emergence of palpitations is a risk factor for atrial fibrillation (AF). Findings of a large population study reveal the strongest risk factors for atrial fibrillation in both men and women to be a history of palpitations and hypertension. Although it is a well-known fact that hypertension is a risk factor for AF, the researchers say, that "the impact of self-reported palpitations on later occurrence of AF has not been documented earlier" ... Education And Income Affect Health Levels Considerably - An annual report on American's health reveals that individuals with lower income levels and lower education are more likely to develop chronic diseases than people with higher incomes and higher levels of education. The report, entitled "Health, United States, 2011" was conducted by CDC's National Center for Health Statistics. Obesity According to the report, in 2007-2010, women aged 25+ were less likely to be obese (25%) if they had a bachelor's degree or higher than women who did not (39-43%) have a degree at all ... Very Sugary Diet Makes You Stupid - As we near the final year exams for schools and universities, students should be wary of powering up on buckets of soda and pocketfuls of candy bars. A UCLA study on rats suggests that fructose slows down the brain and memory functions. Too much sweetness can also prevent learning. The findings are published in Journal of Physiology and also show omega-3 fatty acids helping to negate the effect. Earlier studies have shown that fructose is involved in causing diabetes, obesity and a fatty liver, but this is the first research to uncover how sugar can influence the brain ... Common Antibiotic Found To Carry Heart Risk - Vanderbilt researchers have discovered a rare, but important risk posed by the antibiotic azithromycin, commonly called a "Z-pack." The study found a 2.5-fold higher risk of cardiovascular death in the first five days of taking azithromycin when compared with another common antibiotic or no antibiotics at all. Wayne A. Ray, Ph.D., professor of Preventive Medicine, and C. Michael Stein, M.B.Ch.B., the Dan May Chair in Medicine and professor of Pharmacology, collaborated on the research published in the May 17 edition of the New England Journal of Medicine ... Study Shows Delays In Siblings Of Children With Autism Spectrum Disorders - A new University of Miami (UM) study shows that one in three children who have an older sibling with an Autism Related Disorder (ASD) fall into a group characterized by higher levels of autism-related behaviors or lower levels of developmental progress. The study will be presented at the International Meeting for Autism Research (IMFAR) in May, 2012. ASDs are developmental conditions characterized by problems with social interaction and communication ... Fatal Falls Increase For Older Adults - The recent dramatic increase in the fall death rate in older Americans is likely the effect of improved reporting quality, according to a new report from the Johns Hopkins Center for Injury Research and Policy. The report finds the largest increase in the mortality rate occurred immediately following the 1999 introduction of an update to the International Classification of Diseases (ICD-10), suggesting a major change in the way deaths were classified ... Less Inflammation Seen In Patients With NAFLD, A Common Liver Disease, Who Consume Modest Amounts Of Alcohol - NAFLD (non-alcoholic fatty liver disease) is the most common type of liver disease in the developed world, affecting up to one-third of the US population. NAFLD is often associated with obesity and other parameters of the so-called "metabolic syndrome," which is a major risk factor for the development of cardiovascular disease ... An Estimated 53 Million Americans May Have Diabetes By 2025 - The Diabetes 2025 Model for the U.S. projects a continuous and dramatic increase in the diabetes epidemic and makes it possible to estimate the potential effects of society-wide changes in lifestyle and healthcare delivery systems. Predictions for individual states and population subgroups are highlighted in an article published in Population Health Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Population Health Management website ... Groundbreaking Advance In Medical Diagnostics - Researchers have created an ultrasensitive biosensor that could open up new opportunities for early detection of cancer and "personalized medicine" tailored to the specific biochemistry of individual patients. The device, which could be several hundred times more sensitive than other biosensors, combines the attributes of two distinctly different types of sensors, said Muhammad A. Alam, a Purdue University professor of electrical and computer engineering ... Off-Label Use Of Antipsychotic Medications - Reducing the non-FDA-approved use of antipsychotic drugs may be a way to save money while having little effect on patient care, according to a Penn State College of Medicine study. Researchers say that 57.6 percent of patients prescribed antipsychotic medications in data from 2003 did not have schizophrenia or bipolar disorder, the conditions for which the drugs were approved for use. Use of medication for treatments that is not FDA-approved is called off-label use ... Some Dietary Supplements May Increase Cancer Risk - Beta-carotene, selenium and folic acid - taken up to three times their recommended daily allowance, these supplements are probably harmless. But taken at much higher levels as some supplement manufacturers suggest, these three supplements have now been proven to increase the risk of developing a host of cancers ... Study Shows High-Fructose Diet Sabotages Learning, Memory - Attention, college students cramming between midterms and finals: Binging on soda and sweets for as little as six weeks may make you stupid. A new UCLA rat study is the first to show how a diet steadily high in fructose slows the brain, hampering memory and learning - and how omega-3 fatty acids can counteract the disruption. The peer-reviewed Journal of Physiology has published the findings ... Teaching Hospitals With Fellowship Programs Have Less Radical Prostatectomy Complications - Patients who undergo radical surgery for prostate cancer may expect better results, on average, if they're treated in accredited teaching hospitals with residency programs, and better still if the hospitals also have medical fellowships, according to a new study by Henry Ford Hospital. The study, which evaluated postoperative complications in 47,100 radical prostatectomy (RP) patients throughout the U.S., also found that those with fewer complications after the surgery were more likely to have private insurance ... Under-Use Of Safer Kidney Cancer Surgery For Poorer, Sicker Medicare, Medicaid Patients - An increasingly common and safer type of surgery for kidney cancer is not as likely to be used for older, sicker and poorer patients who are uninsured or rely on Medicare or Medicaid for their health care, according to a new study by researchers at Henry Ford Hospital. The treatment, partial nephrectomy (PN), involves surgically removing only the diseased portion of a cancerous kidney, leaving the unaffected part to continue to function ... Gender Comparison In Kidney Cancer Surgery - Women do better than men after surgical removal of part or all of a cancerous kidney, with fewer post-operative complications, including dying in the hospital, although they are more likely to receive blood transfusions related to their surgery. But Henry Ford Hospital researchers who documented these gender differences can't say why they exist. The results of the new study, based on population samples from throughout the U.S., will be presented this week at the American Urological Association's Annual Meeting in Atlanta. "This is a controversial area," says Quoc-Dien Trinh, M.D ... Food Cravings Reduced By Lizard Saliva - A drug made from the saliva of the Gila monster lizard is effective in reducing the craving for food. Researchers at the Sahlgrenska Academy, University of Gothenburg, have tested the drug on rats, who after treatment ceased their cravings for both food and chocolate. An increasing number of patients suffering from type 2 diabetes are offered a pharmaceutical preparation called Exenatide, which helps them to control their blood sugar ... Most People Brush Their Teeth The Wrong Way - Almost all Swedes brush their teeth, yet only one in ten does it in a way that effectively prevents tooth decay. Now researchers at the Sahlgrenska Academy, University of Gothenburg, are eager to teach Swedes how to brush their teeth more effectively. Most Swedes regularly brush their teeth with fluoride toothpaste. But only few know the best brushing technique, how the toothpaste should be used and how fluoride prevents tooth decay ... Racial Disparities Revealed In Prostate Cancer Surgery - Black prostate cancer patients may not be getting the same quality of care as white patients, according to a first-of-its-kind study by researchers at Henry Ford Hospital who found racial disparities in the results of surgery to remove diseased prostates ... Fertility For Older, Highly Educated Women Has Risen Since The 1990s, According To New Research - An increasing number of highly educated women are opting for families, according to a national study co-authored by a University at Buffalo economist. Qingyan Shang, an assistant professor at UB, says the study uncovers what may be the reversal of a trend by highly educated women. She says it is still too early to be certain, but the research clearly shows fertility rising for older, highly educated women since the 1990s. (Fertility is defined as the number of children a woman has had.) Childlessness also declined by roughly 5 percentage points between 1998 and 2008 ... The Favored Treatment For Kidney Cancer Is Robot-Assisted Surgery - Robot-assisted surgery has replaced another minimally invasive operation as the main procedure to treat kidney cancer while sparing part of the diseased organ, and with comparable results, according to a new research study by Henry Ford Hospital urologists. While the study shows that robot-assisted partial nephrectomy (RAPD), available only since 2004, may also offer fewer complications than laparoscopic partial nephrectomy (LPN), the researchers cautioned that available data did not allow them to consider such factors as surgical expertise and the complexity of each cancer ... Resiliency During Early Years Can Protect Against Later Alcohol/Drug Use - Resiliency is a measure of a person's ability to flexibly adapt their behaviors to fit the surroundings in which they find themselves. Low resiliency during childhood has been linked to later alcohol/drug problems during the teenage years. A new study has examined brain function and connectivity to assess linkages between resiliency and working memory, finding that higher resiliency may be protective against later alcohol/drug use. Results will be published in the August 2012 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View ... Comparison Of On-Premises and Off-Premises Alcohol Outlets and Links To Crime - Prior research has shown that neighborhoods with higher densities of alcohol outlets are more likely to have higher rates of violent crimes. This study examined the effects of different types of alcohol outlets - on-premises such as bars and restaurants, and off-premises such as liquor and convenience stories - on four different categories of crime in urban neighborhoods. Results show a stronger relationship between density of outlets and crime for on- rather than off-premises outlets ... Possible Link Between Early Alcohol Use, Alcohol Dependence, Daily Nicotine Use, And Fewer Years Of Educational Attainment - Although various kinds of substance use are associated with reduced educational attainment, these associations have been mixed and may also be partially due to risk factors such as socioeconomic disadvantages. A study of substance use and education among male twins from a veteran population has found a strong relationship among early alcohol use, alcohol dependence, daily nicotine use, and fewer years of educational attainment. Results will be published in the August 2012 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View ... Examining Adaptive Abilities In Children With Prenatal Alcohol Exposure And/or ADHD - Prenatal exposure to alcohol often results in disruption to the brain's cognitive and behavioral domains, which include executive function (EF) and adaptive functioning. A study of these domains in children with heavy prenatal alcohol exposure (PAE), non-exposed children with attention-deficit/hyperactivity disorder (ADHD), and children without PAE or ADHD has found that, despite similarities in the relation between EF and adaptive abilities among children with ADHD or PAE, the patterns of abilities in these children were different ... Focusing On New Directions Of Viral Hepatitis Care And Research - The editors of Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute, are pleased to announce the publication of this year's highly anticipated special 13th issue. Published each May, the 13th issue is devoted to a particular gastroenterological topic of broad interest; this year's topic is viral hepatitis. In conjunction with editor-in-chief M. Bishr Omary, MD, PhD, this issue was developed by Gastroenterology's experts in viral hepatitis: Senior Associate Editor Anna S. Lok, MD, AGAF, and Associate Editor Jean-Michel Pawlotsky, MD, PhD ... Insight Into Brain Regeneration And Developmental Disorders From Mice With Big Brains - Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that mice that lack a gene called Snf2l have brains that are 35 per cent larger than normal. The research, led by Dr. David Picketts and published in the prestigious journal Developmental Cell, could lead to new approaches to stimulate brain regeneration and may provide important insight into developmental disorders such as autism and Rett syndrome. Dr ... Unexpected Source Of Diabetic Neuropathy Pain Discovered - Nearly half of all diabetics suffer from neuropathic pain, an intractable, agonizing and still mysterious companion of the disease. Now Yale researchers have identified an unexpected source of the pain and a potential target to alleviate it. A team of researchers from Yale and the West Haven Veterans Affairs Medical Center describes in the Journal of Neuroscience how changes in the structure of dendritic spines - microscopic projections on the receiving branches of nerve cells - are associated with pain in laboratory rats with diabetes ... Using Antioxidants To Stabilize Fanconi Anemia - Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000. People affected by this disease have defects in DNA repair, and are hypersensitive to oxidative damage, resulting in bone marrow failure and an increased predisposition to cancer. New research published in BioMed Central's open access journal Orphanet Journal of Rare Diseases shows that a combination of the fatty acid α-lipoic acid (α-LA) and N-acetylcysteine (NAC) can stabilize the DNA of blood cells from FA patients, and drastically reduce its instability. 15 genes are known to be involved in FA ... Potential To Predict Parkinson's Disease Via Colonoscopy Or Flexible Sigmoidoscopy - Two studies by neurological researchers at Rush University Medical Center suggest that, in the future, colonic tissue obtained during either colonoscopy or flexible sigmoidoscopy may be used to predict who will develop Parkinson's disease, a neurodegenerative disorder of aging that that leads to progressive deterioration of motor function due to loss of neurons in the brain that produce dopamine, a neurotransmitter essential to executing movement. Currently, Parkinson's disease afflicts almost 5 million people worldwide ... New Mechanism For Anxiety Disorders Revealed By Mystery Gene - A novel mechanism for anxiety behaviors, including a previously unrecognized inhibitory brain signal, may inspire new strategies for treating psychiatric disorders, University of Chicago researchers report. By testing the controversial role of a gene called Glo1 in anxiety, scientists uncovered a new inhibitory factor in the brain: the metabolic by-product methylglyoxal. The system offers a tantalizing new target for drugs designed to treat conditions such as anxiety disorder, epilepsy, and sleep disorders ... Potential Breast Cancer Vaccine Combination Therapy - A vaccine that targets cancer cells in combination with the drug letrozole, a standard hormonal therapy against breast cancer, significantly increased survival when tested in mice, a team of UC Davis investigators has found. The findings were published in the journal Clinical Cancer Research. "We found that the vaccine and the hormonal drug letrozole were more effective when given together," said Michael DeGregorio, UC Davis professor of hematology and oncology and principal investigator of the study ... Predicting Arthritis At Much Earlier Stage With New Biomarker Test - More than 27 million adults currently suffer from osteoarthritis, which is the most common form of arthritis. In the past, doctors have been unable to diagnose patients with arthritis until they begin to show symptoms, which include joint pain and stiffness. By the time these symptoms are present, it is often too late for preventive and minimally invasive treatment options to be effective. Now, a research team from the University of Missouri's Comparative Orthopaedic Laboratory has found a way to detect and predict arthritis before patients begin suffering from symptoms ... Valuable Tool In Lung Cancer Screening - Video-Assisted Thoracic Surgery - The most recent research released in June's Journal of Thoracic Oncology says video assisted thoracic surgery (VATS) is a valuable tool in managing lesions detected in a lung cancer screening program. The primary objective of lung cancer screening with low dose computer tomography (CT) is to detect lung cancer at an early stage and thus amenable to a complete surgical resection, the only established cure for lung cancer. Lung cancer currently has no standard screening program and less than one third of lung cancer patients present with early stage disease amenable to cure ... Possible Diagnostic Technique For Lung Cancer Screening - The most recent research released in June's Journal of Thoracic Oncology says molecular biomarkers in the tissue and fluid lining the lungs might be an additional predictive technique for lung cancer screening. Since the National Lung Screening Trial found that 96.4 percent of the positive CT screening results were false positive, scientists have been looking for ways to more accurately diagnose patients. This research focused on a way to determine if the nodules detected by the CT screening, are in fact malignant or benign ... Tumor Size May Predict Chemotherapy's Effect On Overall Survival In Non-Small Cell Lung Cancer - The most recent research released in June's Journal of Thoracic Oncology indicates there might be a positive correlation between tumor size and adjuvant platinum based chemotherapy in surgically resected patients with node negative non-small cell lung cancer. The study, published in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, analyzed the effect of tumor size and KRAS mutations on survival benefit from adjuvant platinum based chemotherapy in patients with node negative non-small cell lung cancer ... Study Of A Pediatric Cancer Finds All Cancer Cells Are Not Created Equal - A study from Massachusetts General Hospital (MGH) researchers suggests that specific populations of tumor cells have different roles in the process by which tumors make new copies of themselves and grow. In their report in Cancer Cell, researchers identify a tumor-propagating cell required for the growth of a pediatric muscle tumor in a zebrafish model and also show that another, more-differentiated tumor cell must first travel to sites of new tumor growth to prepare an environment that supports metastatic growth ... Rectal Cancer Patients May Not Be Receiving Treatment Consistent With Guidelines - Research from the University of Alberta provides new insight into treatment patterns for people with stage two and three rectal cancer - information that ultimately will help physicians improve care strategies for patients province-wide. Lead researcher Marcy Winget, an epidemiologist with the School of Public Health, says the study of more than 900 patients with rectal cancer is a first step to addressing gaps in care and ensuring that general practitioners, surgeons and oncologists improve co-ordination of treatment for patients ... Idiopathic Toe Walking And Rotator Cuff Surgery Highlighted In May JAAOS - Treatments for Idiopathic Toe Walking Based on Child's Age and Severity of Gait Abnormality Most children develop a normal walking pattern, or gait, by age 2. And while some toe walking - where a child primarily walks on the front of the foot or toes, never touching the heel to the ground - is common, persistent toe walking beyond age 2 may indicate a neurological disorder. A review article, "Idiopathic Toe Walking," outlines the appropriate steps for effectively diagnosing and treating pediatric toe walking when the cause of the disorder is unknown ... New Inflammation Hormone Link May Pave Way To Study New Drugs For Type 2 Diabetes - A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found. Drugs for type 2 diabetes commonly target insulin, which lowers blood glucose levels. But the U-M study suggests that glucagon - a pancreas-produced hormone that has the opposite effect of insulin by raising blood glucose levels - may also provide a powerful pathway to preventing and treating the increasingly prevalent disease ... Women Seen As Objects, Not People In Sexualized Images - Perfume ads, beer billboards, movie posters: everywhere you look, women's sexualized bodies are on display. A new study published in Psychological Science, a journal of the Association for Psychological Science, finds that both men and women see images of sexy women's bodies as objects, while they see sexy-looking men as people. Sexual objectification has been well studied, but most of the research is about looking at the effects of this objectification ... Findings Suggest The Possibility Of Boosting The Health Benefits Of Omega-3 Oils - For the first time, researchers at the University of California, San Diego have peered inside a living mouse cell and mapped the processes that power the celebrated health benefits of omega-3 fatty acids. More profoundly, they say their findings suggest it may be possible to manipulate these processes to short-circuit inflammation before it begins, or at least help to resolve inflammation before it becomes detrimental. The work is published in the online Early Edition of the Proceedings of the National Academy of Sciences ... Obama's Grand Plan To Cure Alzheimer's - Obama's healthcare goals have been controversial at best, and although anti-smoking campaigns and other public health and safety awareness drives have been successful, it's always somewhat dubious when government starts creating grand plans and lofty goals. Nonetheless, Health and Human Services Secretary Kathleen Sebelius has released an ambitious and wide ranging national plan to fight Alzheimer's disease ... Thought Controlled Robotic Arm For Paralyzed Patients - The journal Nature reports on a science fiction style jump in technology, where an interface on the brain is used to connect to a robotic arm and provide real time thought control. It is a dramatic leap for the technology which has been tested with paralyzed patients and gives hope for Stars Wars style bionic technology, for wounded soldiers and paraplegics. The experiment was conducted on April 12th this year at Brown University in Providence, Rhode Island ... Beijing Olympics Air Pollution Change Impacted On People's Health - A study featured in the May 16 edition of JAMA shows that changes in air pollution during the 2008 Beijing Olympics were related to changes in biomarkers of systemic inflammation and thrombosis, in addition to measure of cardiovascular physiology in healthy young people. The study's background information states: "Air pollution is a risk factor for cardiovascular diseases (CVD), but the mechanisms by which air pollution leads to CVD is not well understood ... AIDS Relief Program Intensity Linked To Lower Death Rates - The May 16 edition of the Global Health themed issue of JAMA reveals a larger drop in all-cause adult mortality in those African countries with more intense operation of the AIDS relief program PEPFAR. The article's background information states: "The effect of global health initiatives on population health is uncertain. Between 2003 and 2008, the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), the largest initiative ever devoted to a single disease, operated intensively in 12 African focus countries ... Child Mortality Rate Decreased After Prenatal Micronutrient, Food Supplementation Internvention - A study in the May 16 edition of JAMA reveals that survival rates of newborns in poor Bangladeshi communities were significantly improved if their mothers received multiple micronutritions, including iron and folic acid combined with early food supplementation during pregnancy, in comparison with women receiving the usual food supplementation. The article's background information says: "Maternal and child undernutrition is estimated to be the underlying cause of 3.5 million annual deaths and 35 percent of the total disease burden in children younger than 5 years ... High Rate Of Malaria And Sexually Transmitted/Reproductive Tract Infections In Sub-Saharan Pregnant Mothers - A review and meta-analysis of studies published in the May 16 theme issue of Global Health in JAMA reveals a significant burden of malaria and STIs/RTIs amongst pregnant women who attend antenatal facilities in sub-Saharan Africa. The findings were discovered after a review of studies reporting estimates of the prevalence of sexually transmitted infections/reproductive tract infections (STIs/RTIs) and malaria over the past 2 decades. The article's background information states: "There are 880,000 stillbirths and 1.2 million neonatal deaths each year in sub-Saharan Africa ... Avoiding Repeat Biopsies In Prostate Cancer - MDxHealth Launches ConfirmMDx - Each year, in the United States, more than 650,000 men receive a negative prostate biopsy result, with around 25-35% of these results being false negative. However, a new prostate cancer test has been launched by MdxHealth. The test - ConfirmMDx? for Prostate Cancer - will help physicians identify which men have a true-negative prostate biopsy from those who may have occult cancer. Professor Dr ... Rising Infertility And Cancer Rates Possibly Linked To Pharmaceuticals And Household Chemicals - According to the European Environment Agency (EEA), household products, cosmetics, pharmaceuticals and food all contain endocrine disrupting chemicals (EDCs) which may be causing significant increases in diabetes, obesity, cancers and increasing infertility. In recent decades, the incidence of many human diseases and disorders including diabetes, breast and prostate cancer, and male infertility has increased significantly and many scientists believe this is due to increasing levels of exposure to mixtures of some chemicals in widespread use ... Specific Clinical Guidance Urgently Needed On Bone Cancer Drugs - Although bisphosphonate drugs can reduce pain and bone fractures in individuals with multiple myeloma, no one drug is superior, according to a systematic review of the current evidence of these drugs. The review is published in The Cochrane Library. Multiple myeloma is a type of cancer that grows in and on bones. The disease can cause fractures in the spine and long bones. Bisphosphonate drugs are used to prevent or reduce the occurrence of bone fractures and pain in these patients and work by inhibiting the activities of osteoclasts (bone cells) ... Advanced Soft Tissue Sarcoma, Pazopanib Improves Progression-Free Survival - According to results of the PALETTE trial, treatment with pazopanib increased progression-free survival (PFS) almost three fold among patients with metastatic soft-tissue sarcoma whose disease had progressed following chemotherapy. The results are published Online First in The Lancet. In the United States, an estimated 11,000 individuals are diagnosed with soft-tissue sarcomas each year - accounting for just 1% of all adult cancers. However, progress in developing new effective treatments for the disease has been slow during the last three decades ... Cell Signaling Breakthrough May Help Melanoma Treatment - The body's function of generating new cells and replacing dead ones usually works fine, but it is by no means perfect. The key to generating new cells is communication or signaling between cells, and if this process does not function properly, it can lead to uncontrolled cell growth, which is the basis for many cancers. A key discovery made by scientists from the Texas University Health Science Center at Houston (UTHealth) Medical School reveals that cell signaling plays an important role in the fight against melanoma and various other fast-spreading tumors ... Marker To Identify, Attack Breast Cancer Stem Cells - Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of Texas MD Anderson Cancer Center report online in Journal of Clinical Investigation. "We've discovered the first single marker for breast cancer stem cells and also found that it's targetable with a small molecule drug that inhibits an enzyme crucial to its synthesis," said co-senior author Michael Andreeff, M.D., Ph.D ... After Stem Cell Transplant For Multiple Myeloma Patients, Lenalidomide Prolongs Disease Control - Multiple myeloma patients are better equipped to halt progression of this blood cancer if treated with lenalidomide, or Revlimid®, following a stem cell transplant, according to a study co-authored by a physician with the Oregon Health & Science University Knight Cancer Institute. The study, published in the New England Journal of Medicine, found a 63 percent reduction in the risk of progressive myeloma or death for the stem cell transplant patients that were treated with lenalidomide maintenance therapy ... Apigenin Slowed Progression Of Breast Cancer Accelerated By Hormone Replacement Therapy - Apigenin, a natural substance found in grocery store produce aisles, shows promise as a non-toxic treatment for an aggressive form of human breast cancer, following a new study at the University of Missouri. MU researchers found apigenin shrank a type of breast cancer tumor that is stimulated by progestin, a synthetic hormone given to women to ease symptoms related to menopause ... Copyright © 2012, Ephedra-Bestfatburner. All Rights Reserved. Buy Ephedra Products |